• Classify distinct functions of isoforms
  • Literature-based analysis of experimental evidence for functionally distinct splice isoforms (FDSIs) for over 700 human & mouse genes
  • Result: fewer than 10% of genes have solid experimental evidences of FDSIs.

Main

Some question

  • Do most genes really have multiple functional isoforms?
  • Given that only 3% of human and 9% of mouse genes have evidence for FDSIs
  • Trying to link FDSIs back to sequence databases: 25/39
  • Isoforms of 1/3 genes mentioned cannot be matched to transcripts in ENSEMBL

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